Toisto: Täyspitkä APP ( english), LTP modulaatio

(KTS Dementia sarja 1. 3.2. )

“3.2. Amyloid and plasticity.
Full length APP influences cell-substrate interactions during neurite extension,
promotes the formation and maintenance of synapses in the CNS,
modulates LTP and protects neurons against excitotoxic and oxidative insults.
The soluble/secreted APP (sAPP) also displays plasticity promoting properties.
This sAPP fragment is released from neurons in response to electrical activity
and induces neurite outgrowth,
experience-related synaptogenesis and LTP (Mattson, 1997).
In contrast to full-length APP and sAPP, the AB fragments of amyloid, especially its long from is neurotoxic and inhibits axonal sprouting as well as LTP.!

FULL-length APP


ORIGIN
1 mlpglallll aawtaralev ptdgnaglla epqiamfcgr lnmhmnvqng kwdsdpsgtk
61 tcidtkegil qycqevypel qitnvveanq pvtiqnwckr grkqckthph fvipyrclvg
121 efvsdallvp dkckflhqer mdvcethlhw htvaketcse kstnlhdygm llpcgidkfr
181 gvefvccpla eesdnvdsad aeeddsdvww ggadtdyadg sedkvvevae eeevaeveee
241 eadddedded gdeveeeaee pyeeatertt siattttttt esveevvrvp ttaastpdav
301 dkyletpgde nehahfqkak erleakhrer msqvmrewee aerqaknlpk adkkaviqhf
361 qekvesleqe aanerqqlve thmarveaml ndrrrlalen yitalqavpp rprhvfnmlk
421 kyvraeqkdr qhtlkhfehv rmvdpkkaaq irsqvmthlr viyermnqsl sllynvpava
481 eeiqdevdel lqkeqnysdd vlanmisepr isygndalmp sltetkttve llpvngefsl
541 ddlqpwhsfg adsvpanten evepvdarpa adrglttrpg sgltniktee isevkmdaef
601 rhdsgyevhh qklvffaedv gsnkgaiigl mvggvviatv ivitlvmlkk kqytsihhgv
661 vevdaavtpe erhlskmqqn gyenptykff eqmqn
//
JOURNAL Submitted (15-NOV-1988)
FEATURES Location/Qualifiers
source 1..695
/organism="Homo sapiens"
/db_xref="taxon:9606"
/tissue_type="cortex of brain"
/dev_stage="5-month-old aborted fetus"
Protein 1..695
/name="unnamed protein product"
Region 24..188
/region_name="A4_EXTRA"
/note="amyloid A4; amyloid A4 precursor of Alzheimers
disease; smart00006"
/db_xref="CDD:47362"
Region <309 ..505="" db_xref="CDD:30768" note="ATPase involved in DNA repair [DNA replication, recombination, and repair]; COG0419" region_name="SbcC">630
/region_name="Beta-APP"
/note="Beta-amyloid peptide (beta-APP); pfam03494"
/db_xref="CDD:43420"
CDS 1..695
/coded_by="Y00264.1:148..2235"
/note="precursor polypeptide (AA 1-695)"
http://www.ncbi.nlm.nih.gov/entrez/viewer.fcgi?val=CAA68374.1