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tisdag 18 oktober 2016

Onko miesten ja naisten K1-vitamiinitarve sama painokiloa kohden?

 Otsikon kysymys: Ainakin naisilla K-vitamiinintarve riippuu fysiologisista vaiheista, kuten raskausajasta, imetyksestä, jolloin tarve on suurempi tai ainakin  "otettava huomioon", Lapsilla tarve on otettava huomuoon  varhaisvaiheessa synnytyksen jälkeisinä kuukausina.  Seuraava vaihe, jossa asiaa pohditaan on  Marevanin tarve loppuiällä eri tautien takia.

https://www.ncbi.nlm.nih.gov/pubmed/25772619

Biochem Biophys Res Commun. 2015 May 1;460(2):238-44. doi: 10.1016/j.bbrc.2015.03.018. Epub 2015 Mar 12.

YY1 positively regulates human UBIAD1 expression.

Abstract

Vitamin K is involved in bone formation and blood coagulation. Natural vitamin K compounds are composed of the plant form phylloquinone (vitamin K1) and a series of bacterial menaquionones (MK-n; vitamin K2). Menadione (vitamin K3) is an artificial vitamin K compound.

MK-4 contains 4-isoprenyl as a side group in the 2-methyl-1,4-naphthoquinone common structure and has various bioactivities.

UbiA prenyltransferase domain containing 1 (UBIAD1 or TERE1) is the menaquinone-4 biosynthetic enzyme.

 UBIAD1 transcript expression significantly decreases in patients with prostate carcinoma and overexpressing  UBIAD1 inhibits proliferation of a tumour cell line.
 UBIAD1 mRNA expression is ubiquitous in mouse tissues, and higher UBIAD1 mRNA expression levels are detected in the brain, heart, kidneys and pancreas.

Several functions of UBIAD1 have been reported; however, regulation of the human UBIAD1 gene has not been elucidated.

Here we report cloning and characterisation of the human UBIAD1 promoter. A 5' rapid amplification of cDNA ends analysis revealed that the main transcriptional start site was 306 nucleotides upstream of the translation initiation codon.

 Deletion and mutation analyses revealed the functional importance of the YY1 consensus motif. Electrophoretic gel mobility shift and chromatin immunoprecipitation assays demonstrated that YY1 binds the UBIAD1 promoter in vitro and in vivo.

In addition, YY1 small interfering RNA decreased endogenous UBIAD1 mRNA expression and UBIAD1 conversion activity. These results suggest that YY1 up-regulates UBIAD1 expression and UBIAD1 conversion activity through the UBIAD1 promoter.

KEYWORDS:

Gene regulation; UBIAD1; Vitamin K; YY1
PMID:
25772619
DOI:
10.1016/j.bbrc.2015.03.018

Hakusana: Myeliinisynteesi, D-vitamiini


de la Fuente AG, Errea O, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJ.
J Cell Biol. 2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119. The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.
2.
Spanier JA, Nashold FE, Mayne CG, Nelson CD, Hayes CE.
J Neuroimmunol. 2015 Sep 15;286:48-58. doi: 10.1016/j.jneuroim.2015.06.015. Epub 2015 Jul 4. Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on the axon-myelin unit. A female MS bias becomes evident after puberty and female incidence has tripled in the last half-century, implicating a female sex hormone interacting with a modifiable environmental factor. These aspects of MS suggest that many female MS cases may be preventable. Mechanistic knowledge of this hormone-environment interaction is needed to devise strategies to reduce female MS risk. We previously demonstrated that vitamin D3 (D3) deficiency increases and D3 supplementation decreases experimental autoimmune encephalomyelitis (EAE) risk in a female-biased manner.
PMID:
26298324
3.
Chiuso-Minicucci F, Ishikawa LL, Mimura LA, Fraga-Silva TF, França TG, Zorzella-Pezavento SF, Marques C, Ikoma MR, Sartori A.
PLoS One. 2015 May 12;10(5):e0125836. doi: 10.1371/journal.pone.0125836. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0131260.
PMID:
25965341
 https://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein
Kysymys: vaatiiko tämä proteiini posttranslationaalsita karboksylaatiota Glu- tähteeseen? 
Free PMC Article
4.
Mohammadi-Kordkhayli M, Ahangar-Parvin R, Azizi SV, Nemati M, Shamsizadeh A, Khaksari M, Moazzeni SM, Jafarzadeh A.
Iran J Immunol. 2015 Mar;12(1):35-49. doi: IJIv12i1A4.
PMID:
25784096
5.
Zhen C, Feng X, Li Z, Wang Y, Li B, Li L, Quan M, Wang G, Guo L.
J Neuroimmunol. 2015 Mar 15;280:1-7. doi: 10.1016/j.jneuroim.2015.01.012. Epub 2015 Jan 29.
PMID:
25773147
6.
Waddell A, Zhao J, Cantorna MT.
Int Immunol. 2015 May;27(5):237-44. doi: 10.1093/intimm/dxu147. Epub 2015 Jan 8.
7.
Wang Y, Marling SJ, Beaver EF, Severson KS, Deluca HF.
Arch Biochem Biophys. 2015 Feb 1;567:75-82. doi: 10.1016/j.abb.2014.12.017. Epub 2014 Dec 23.
PMID:
25541149
8.
Mansilla MJ, Sellès-Moreno C, Fàbregas-Puig S, Amoedo J, Navarro-Barriuso J, Teniente-Serra A, Grau-López L, Ramo-Tello C, Martínez-Cáceres EM.
CNS Neurosci Ther. 2015 Mar;21(3):222-30. doi: 10.1111/cns.12342. Epub 2014 Nov 18.
PMID:
25403984
9.
Paintlia MK, Singh I, Singh AK.
J Neurosci Res. 2015 Jan;93(1):28-42. doi: 10.1002/jnr.23476. Epub 2014 Sep 19.
10.
Sakai S, Suzuki M, Tashiro Y, Tanaka K, Takeda S, Aizawa K, Hirata M, Yogo K, Endo K.
J Bone Miner Res. 2015 Jan;30(1):128-36. doi: 10.1002/jbmr.2317.
11.
Millet P, Landel V, Virard I, Morello M, Féron F.
Biol Aujourdhui. 2014;208(1):77-88. doi: 10.1051/jbio/20140007. Epub 2014 Jun 23. Review. French.
PMID:
24948021
12.
Nystad AE, Wergeland S, Aksnes L, Myhr KM, Bø L, Torkildsen O.
APMIS. 2014 Dec;122(12):1178-86. doi: 10.1111/apm.12281. Epub 2014 May 26.
PMID:
24862867
13.
Adamo AM.
Genes Nutr. 2014 Jan;9(1):360. doi: 10.1007/s12263-013-0360-8. Epub 2013 Dec 6.
14.
Slavov GS, Trenova AG, Manova MG, Kostadinova II, Vasileva TV, Zahariev ZI.
Folia Med (Plovdiv). 2013 Apr-Jun;55(2):5-9. Review.
PMID:
24191393
15.
Shaygannejad V, Tolou-Ghamari Z.
Int J Prev Med. 2013 May;4(Suppl 2):S159-64.
16.
Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, Legre R, Khrestchatisky M, Decherchi P, Feron F.
PLoS One. 2013 May 31;8(5):e65034. doi: 10.1371/journal.pone.0065034. Print 2013.
17.
Koch MW, Metz LM, Kovalchuk O.
Nat Rev Neurol. 2013 Jan;9(1):35-43. doi: 10.1038/nrneurol.2012.226. Epub 2012 Nov 20. Review.
PMID:
23165337
18.
Grau-López L, Granada ML, Raïch-Regué D, Naranjo-Gómez M, Borràs-Serres FE, Martínez-Cáceres E, Ramo-Tello C.
BMC Neurol. 2012 Sep 24;12:103. doi: 10.1186/1471-2377-12-103.
19.
Mason DL, Assimon MM, Bishop JR, El-Fawal HA.
Hemodial Int. 2013 Jan;17(1):3-11. doi: 10.1111/j.1542-4758.2012.00727.x. Epub 2012 Aug 15.
20.
Lommers E, Lecrompe L, Moonen G, Phan-Ba R, Belachew S.
Rev Med Liege. 2012 May-Jun;67(5-6):359-65. Review. French.
PMID:
22891491