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tisdag 18 oktober 2016

Hakusana: Myeliinisynteesi, D-vitamiini


Vitamin D receptor-retinoid X receptor heterodimer signaling regulates oligodendrocyte progenitor cell differentiation.
de la Fuente AG, Errea O, van Wijngaarden P, Gonzalez GA, Kerninon C, Jarjour AA, Lewis HJ, Jones CA, Nait-Oumesmar B, Zhao C, Huang JK, ffrench-Constant C, Franklin RJ.
J Cell Biol. 2015 Dec 7;211(5):975-85. doi: 10.1083/jcb.201505119. The mechanisms regulating differentiation of oligodendrocyte (OLG) progenitor cells (OPCs) into mature OLGs are key to understanding myelination and remyelination. Signaling via the retinoid X receptor γ (RXR-γ) has been shown to be a positive regulator of OPC differentiation. However, the nuclear receptor (NR) binding partner of RXR-γ has not been established. In this study we show that RXR-γ binds to several NRs in OPCs and OLGs, one of which is vitamin D receptor (VDR). Using pharmacological and knockdown approaches we show that RXR-VDR signaling induces OPC differentiation and that VDR agonist vitamin D enhances OPC differentiation. We also show expression of VDR in OLG lineage cells in multiple sclerosis. Our data reveal a role for vitamin D in the regenerative component of demyelinating disease and identify a new target for remyelination medicines.
PMID:
26644513
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2.
Vitamin D and estrogen synergy in Vdr-expressing CD4(+) T cells is essential to induce Helios(+)FoxP3(+) T cells and prevent autoimmune demyelinating disease.
Spanier JA, Nashold FE, Mayne CG, Nelson CD, Hayes CE.
J Neuroimmunol. 2015 Sep 15;286:48-58. doi: 10.1016/j.jneuroim.2015.06.015. Epub 2015 Jul 4. Multiple sclerosis (MS) is a neurodegenerative disease resulting from an autoimmune attack on the axon-myelin unit. A female MS bias becomes evident after puberty and female incidence has tripled in the last half-century, implicating a female sex hormone interacting with a modifiable environmental factor. These aspects of MS suggest that many female MS cases may be preventable. Mechanistic knowledge of this hormone-environment interaction is needed to devise strategies to reduce female MS risk. We previously demonstrated that vitamin D3 (D3) deficiency increases and D3 supplementation decreases experimental autoimmune encephalomyelitis (EAE) risk in a female-biased manner.
PMID:
26298324
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3.
Treatment with Vitamin D/MOG Association Suppresses Experimental Autoimmune Encephalomyelitis.
Chiuso-Minicucci F, Ishikawa LL, Mimura LA, Fraga-Silva TF, França TG, Zorzella-Pezavento SF, Marques C, Ikoma MR, Sartori A.
PLoS One. 2015 May 12;10(5):e0125836. doi: 10.1371/journal.pone.0125836. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0131260.
PMID:
25965341
 https://en.wikipedia.org/wiki/Myelin_oligodendrocyte_glycoprotein
Kysymys: vaatiiko tämä proteiini posttranslationaalsita karboksylaatiota Glu- tähteeseen? 
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4.
Vitamin D Modulates the Expression of IL-27 and IL-33 in the Central Nervous System in Experimental Autoimmune Encephalomyelitis (EAE).
Mohammadi-Kordkhayli M, Ahangar-Parvin R, Azizi SV, Nemati M, Shamsizadeh A, Khaksari M, Moazzeni SM, Jafarzadeh A.
Iran J Immunol. 2015 Mar;12(1):35-49. doi: IJIv12i1A4.
PMID:
25784096
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5.
Suppression of murine experimental autoimmune encephalomyelitis development by 1,25-dihydroxyvitamin D3 with autophagy modulation.
Zhen C, Feng X, Li Z, Wang Y, Li B, Li L, Quan M, Wang G, Guo L.
J Neuroimmunol. 2015 Mar 15;280:1-7. doi: 10.1016/j.jneuroim.2015.01.012. Epub 2015 Jan 29.
PMID:
25773147
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6.
NKT cells can help mediate the protective effects of 1,25-dihydroxyvitamin D3 in experimental autoimmune encephalomyelitis in mice.
Waddell A, Zhao J, Cantorna MT.
Int Immunol. 2015 May;27(5):237-44. doi: 10.1093/intimm/dxu147. Epub 2015 Jan 8.
PMID:
25574039
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7.
UV light selectively inhibits spinal cord inflammation and demyelination in experimental autoimmune encephalomyelitis.
Wang Y, Marling SJ, Beaver EF, Severson KS, Deluca HF.
Arch Biochem Biophys. 2015 Feb 1;567:75-82. doi: 10.1016/j.abb.2014.12.017. Epub 2014 Dec 23.
PMID:
25541149
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8.
Beneficial effect of tolerogenic dendritic cells pulsed with MOG autoantigen in experimental autoimmune encephalomyelitis.
Mansilla MJ, Sellès-Moreno C, Fàbregas-Puig S, Amoedo J, Navarro-Barriuso J, Teniente-Serra A, Grau-López L, Ramo-Tello C, Martínez-Cáceres EM.
CNS Neurosci Ther. 2015 Mar;21(3):222-30. doi: 10.1111/cns.12342. Epub 2014 Nov 18.
PMID:
25403984
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9.
Effect of vitamin D3 intake on the onset of disease in a murine model of human Krabbe disease.
Paintlia MK, Singh I, Singh AK.
J Neurosci Res. 2015 Jan;93(1):28-42. doi: 10.1002/jnr.23476. Epub 2014 Sep 19.
PMID:
25236689
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10.
Vitamin D receptor signaling enhances locomotive ability in mice.
Sakai S, Suzuki M, Tashiro Y, Tanaka K, Takeda S, Aizawa K, Hirata M, Yogo K, Endo K.
J Bone Miner Res. 2015 Jan;30(1):128-36. doi: 10.1002/jbmr.2317.
PMID:
25043694
Free Article
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11.
[Role of vitamin D in the physiopathology of neurodegenerative diseases].
Millet P, Landel V, Virard I, Morello M, Féron F.
Biol Aujourdhui. 2014;208(1):77-88. doi: 10.1051/jbio/20140007. Epub 2014 Jun 23. Review. French.
PMID:
24948021
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12.
Effect of high-dose 1.25 dihydroxyvitamin D3 on remyelination in the cuprizone model.
Nystad AE, Wergeland S, Aksnes L, Myhr KM, Bø L, Torkildsen O.
APMIS. 2014 Dec;122(12):1178-86. doi: 10.1111/apm.12281. Epub 2014 May 26.
PMID:
24862867
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13.
Nutritional factors and aging in demyelinating diseases.
Adamo AM.
Genes Nutr. 2014 Jan;9(1):360. doi: 10.1007/s12263-013-0360-8. Epub 2013 Dec 6.
PMID:
24311441
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14.
Vitamin D immunomodulatory potential in multiple sclerosis.
Slavov GS, Trenova AG, Manova MG, Kostadinova II, Vasileva TV, Zahariev ZI.
Folia Med (Plovdiv). 2013 Apr-Jun;55(2):5-9. Review.
PMID:
24191393
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15.
What is the Real Fate of Vitamin D in Multiple Sclerosis?
Shaygannejad V, Tolou-Ghamari Z.
Int J Prev Med. 2013 May;4(Suppl 2):S159-64.
PMID:
23776718
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16.
Cholecalciferol (vitamin D₃) improves myelination and recovery after nerve injury.
Chabas JF, Stephan D, Marqueste T, Garcia S, Lavaut MN, Nguyen C, Legre R, Khrestchatisky M, Decherchi P, Feron F.
PLoS One. 2013 May 31;8(5):e65034. doi: 10.1371/journal.pone.0065034. Print 2013.
PMID:
23741446
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17.
Epigenetic changes in patients with multiple sclerosis.
Koch MW, Metz LM, Kovalchuk O.
Nat Rev Neurol. 2013 Jan;9(1):35-43. doi: 10.1038/nrneurol.2012.226. Epub 2012 Nov 20. Review.
PMID:
23165337
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18.
Regulatory role of vitamin D in T-cell reactivity against myelin peptides in relapsing-remitting multiple sclerosis patients.
Grau-López L, Granada ML, Raïch-Regué D, Naranjo-Gómez M, Borràs-Serres FE, Martínez-Cáceres E, Ramo-Tello C.
BMC Neurol. 2012 Sep 24;12:103. doi: 10.1186/1471-2377-12-103.
PMID:
23006125
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19.
Nervous system autoantibodies and vitamin D receptor gene polymorphisms in hemodialysis patients.
Mason DL, Assimon MM, Bishop JR, El-Fawal HA.
Hemodial Int. 2013 Jan;17(1):3-11. doi: 10.1111/j.1542-4758.2012.00727.x. Epub 2012 Aug 15.
PMID:
22897631
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20.
[Vitamin D tweets light to genes in multiple sclerosis].
Lommers E, Lecrompe L, Moonen G, Phan-Ba R, Belachew S.
Rev Med Liege. 2012 May-Jun;67(5-6):359-65. Review. French.
PMID:
22891491
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