Orexin reseptori-2 OX2R, Ligandit Orexin-A ja Orexin-B

http://www.genenames.org/cgi-bin/gene_symbol_report?hgnc_id=HGNC:4849

Official Symbol

HCRTR2provided by HGNC

Official Full Name

hypocretin receptor 2provided by HGNC

Also known as

OX2R

Summary

The protein encoded by this gene is a G-protein coupled receptor involved in the regulation of feeding behavior. The encoded protein binds the hypothalamic neuropeptides orexin A and orexin B. A related gene (HCRTR1) encodes a G-protein coupled receptor that selectively binds orexin A. [provided by RefSeq, Jan 2009]

1. Associations between the orexin (hypocretin) receptor 2 gene polymorphism Val308Ile and nicotine dependence in genome-wide and subsequent association studies. Nishizawa D, et al. Mol Brain, 2015 Aug 20. PMID 26289589, Free PMC Article
2. Antibodies to influenza nucleoprotein cross-react with human hypocretin receptor 2. Ahmed SS, et al. Sci Transl Med, 2015 Jul 1. PMID 26136476
3. Crystal structure of the human OX2 orexin receptor bound to the insomnia drug suvorexant. Yin J, et al. Nature, 2015 Mar 12. PMID 25533960
4. Expression of type 2 orexin receptor in human endometrium and its epigenetic silencing in endometrial cancer. Dehan P, et al. J Clin Endocrinol Metab, 2013 Apr. PMID 23482607
5. Genomic organization and regulation of the human orexin (hypocretin) receptor 2 gene: identification of alternative promoters. Chen J, et al. Biochem J, 2010 Apr 14. PMID 20156195

See all (58) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

1. Heart failure patients with minor allele for rs7767652, upstream of hypocretin (orexin) receptor-2 (HCRTR2), were less likely to have improved left ventricular function and a lower prevalence of ejection fraction >35%
2. the nonsynonymous rs2653349 single nucleotide polymorphism (SNP) (located on the gene that encodes orexin [hypocretin] receptor 2) was selected as the most notable SNP associated with Fagerstrom Test for Nicotine Dependence.
3. Antibodies from vaccine-associated narcolepsy sera cross-reacted with both influenza nucleoprotein and hypocretin receptor 2.
4. Decrease in Ox expression with normal human maturation and aging. This may contribute to changes in sleep regulation during development and with aging.
5. The genotypic and allelic frequencies of the rs2653349 polymorphism were different between Alzheimer's disease patients and controls. The carriage of the G allele was associated with an increased AD risk.
6. using lipid-mediated crystallization and protein engineering with a novel fusion chimaera, the structure of the human OX2R bound to suvorexant at 2.5 A resolution is solved
7. DQ B1 but not HLA-DR typing, TNF-alpha levers, HCRTR1 and HCRTR2 were higher in narcolepsy-cataplexy/schizophrenia patients.
8. Both orexin receptor subtypes, OX1R and OX2R, and CB1 cannabinoid receptors are capable of forming constitutive homo- and heteromeric complexes.
9. Orexinergic innervation and expression of genes encoding OX2R receptor are upregulated in transgenic mice at dusk.
10. Expression of the OX2R protein was detected in normal endometrial epithelia, whereas it was frequently lacking in endometrial endometrioid carcinoma.