Orexin-A peptidi ja propeptidi

ORIGIN      
        1 xplpdccrqk tcscrlyell hgagnhaagi ltlx

 http://www.ncbi.nlm.nih.gov/protein/NP_001515.1

ORIGIN      
        1 mnlpstkvsw aavtllllll llppallssg aaaqplpdcc rqktcscrly ellhgagnha
       61 agiltlgkrr sgppglqgrl qrllqasgnh aagiltmgrr agaepaprpc lgrrcsapaa
      121 asvapggqsg i

http://www.ncbi.nlm.nih.gov/gene/3060
Kromosomi 17

HCRTprovided by HGNC

Official Full Name

hypocretin (orexin) neuropeptide precursorprovided by HGNC

Primary source

HGNC:HGNC:4847

See related

Ensembl:ENSG00000161610 HPRD:03836; MIM:602358; Vega:OTTHUMG00000180107

Gene type

protein coding

Also known as

OX; PPOX; NRCLP1

Summary

This gene encodes a hypothalamic neuropeptide precursor protein that gives rise to two mature neuropeptides, orexin A and orexin B, by proteolytic processing. Orexin A and orexin B, which bind to orphan G-protein coupled receptors HCRTR1 and HCRTR2, function in the regulation of sleep and arousal. This neuropeptide arrangement may also play a role in feeding behavior, metabolism, and homeostasis. [provided by RefSeq, Jan 2010]

1. Decreased orexin (hypocretin) immunoreactivity in the hypothalamus and pontine nuclei in sudden infant death syndrome. Hunt NJ, et al. Acta Neuropathol, 2015 Aug. PMID 25953524
2. Elevated plasma orexin A levels in a subgroup of patients with schizophrenia associated with fewer negative and disorganized symptoms. Chien YL, et al. Psychoneuroendocrinology, 2015 Mar. PMID 25560205
3. Reduced serum orexin-A levels in autoimmune encephalitis and neuromyelitis optica patients. Küçükali Cİ, et al. J Neurol Sci, 2014 Nov 15. PMID 25218417
4. Lower wake resting sympathetic and cardiovascular activities in narcolepsy with cataplexy. Donadio V, et al. Neurology, 2014 Sep 16. PMID 25098533
5. Neuropathological investigation of hypocretin expression in brains of dementia with Lewy bodies. Kasanuki K, et al. Neurosci Lett, 2014 May 21. PMID 24704327

See all (99) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

1. Study shows Ox immunoreactivity is decreased in the hypothalamus and pontine nuclei of infants who died from sudden infant death syndrome
2. Results from homology and docking modeling show two alternative binding modes for orexin-A into orexin 1 receptor in concordance with what is known of G protein coupled receptors activation in general and the mutational data.
3. Patients with schizophrenia had a significantly higher plasma HCRT level than healthy controls. Patients in the high-orexin subgroup had significantly fewer negative and disorganized symptoms, and tended to have fewer perseverative errors.
4. Data suggest that interaction between the nociceptin/nociceptin receptor system and the orexin/orexin receptor system in neurons of the hypothalamus positively and negatively modulate complex and integrated responses to stress. [REVIEW]
5. Decrease in Ox expression with normal human maturation and aging. This may contribute to changes in sleep regulation during development and with aging.
6. Orexin A upregulates the protein expression of OX1R and enhances the proliferation of SGC-7901 gastric cancer cells through the ERK signaling pathway.
7. Orexin receptor binding was strongly dependent on the extracellular Ca(2+) concentration.
8. autoimmune encephalitis and neuromyelitis optica patients had significantly lower serum orexin-A levels than both healthy controls and narcolepsy patients
9. No significant differences were found in the distribution of either genotypic or allelic frequencies between Alzheimer's disease cases and controls in the HCRT polymorphisms.
10. Hypocretin, MOG, or DNMT1 mutations are exceptional findings in DQB1*06:02 negative narcolepsy cases with hypocretin deficiency

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