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söndag 17 oktober 2010

TRIP12, thyroid hormone receptor interactor 12

TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. [2008]
Our data suggest that that TRIP12 promotes degradation of APP-BP1 by catalyzing its ubiquitination, which in turn modulates the neddylation pathway. [2008]
Overexpression of TRIP12 enhanced the degradation of APP-BP1, whereas knockdown of TRIP12 stabilized it. [2008]
Immunoprecipitation analysis showed that TRIP12 specifically interacts with the APP-BP1 monomer but not with the APP-BP1/Uba3 heterodimer. [2008]
In vitro ubiquitination assays revealed that TRIP12 functions as an E3 enzyme of APP-BP1 and additionally requires an E4 activity for polyubiquitination of APP-BP1. [2008]
To study biological functions of TRIP12, a HECT domain-containing E3 ubiquitin ligase, we used the yeast two-hybrid system and identified APP-BP1 as its binding partner. [2008]

Kts. APP-BP1 rakennetta.
Se on sikäli pahannäköinen että sen
ubikitinylaatio on tärkeä asia.


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