TRIP12 functions as an E3 ubiquitin ligase of APP-BP1. [2008]
Our data suggest that that TRIP12 promotes degradation of APP-BP1 by catalyzing its ubiquitination, which in turn modulates the neddylation pathway. [2008]
Overexpression of TRIP12 enhanced the degradation of APP-BP1, whereas knockdown of TRIP12 stabilized it. [2008]
Immunoprecipitation analysis showed that TRIP12 specifically interacts with the APP-BP1 monomer but not with the APP-BP1/Uba3 heterodimer. [2008]
In vitro ubiquitination assays revealed that TRIP12 functions as an E3 enzyme of APP-BP1 and additionally requires an E4 activity for polyubiquitination of APP-BP1. [2008]
To study biological functions of TRIP12, a HECT domain-containing E3 ubiquitin ligase, we used the yeast two-hybrid system and identified APP-BP1 as its binding partner. [2008]
http://www.ihop-net.org/UniPub/iHOP/gs/94556.html?ID=94227
Kts. APP-BP1 rakennetta.
Se on sikäli pahannäköinen että sen
ubikitinylaatio on tärkeä asia.
http://www.google.se/imgres?imgurl=http://upload.wikimedia.org/wikipedia/commons/thumb/3/30/Protein_APPBP1_PDB_1r4m.png/250px-Protein_APPBP1_PDB_1r4m.png&imgrefurl=http://en.wikipedia.org/wiki/APPBP1&usg=__ETXRy-_-7EQ6BVndIBH-oENBAWA=&h=197&w=250&sz=87&hl=sv&start=10&zoom=0&um=1&itbs=1&tbnid=uDhwhanDW4c7-M:&tbnh=87&tbnw=111&prev=/images%3Fq%3DTRIP12%2Band%2BAPP-BP1%26um%3D1%26hl%3Dsv%26sa%3DN%26tbs%3Disch:1
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