KBTBD3 /BKLHD3

Tutkimusten alainen Kelch-superperheen  KBTBD-ryhmän  proteiini , jota  ilmentyy eniten aivoissa, siten kilpirauhasessa ja useissa muissa kudoksissa . https://genecards.weizmann.ac.il/v3/cgi-bin/carddisp.pl?gene=KBTBD3: Funktio pohdittavana.
https://genecards.weizmann.ac.il/v3/cgi-bin/carddisp.pl?gene=KBTBD3

HGNC Gene Families:

BTBD: BTB/POZ domain containing Selected InterPro protein domains (see all 7):  IPR017096 Kelch-like_gigaxonin-typ  IPR000210 BTB/POZ-like  IPR006652 Kelch_1  IPR011333 BTB/POZ_fold  IPR013069 BTB_POZ Graphical View of Domain Structure for InterPro Entry Q8NAB2 ProtoNet protein and cluster: Q8NAB2 2 Blocks protein domains: IPB000210 BTB/POZ domain IPB011705 BTB/Kelch-associated UniProtKB/Swiss-Prot: KBTB3_HUMAN, Q8NAB2 Similarity: Contains 1 BACK (BTB/Kelch associated) domain Similarity: Contains 1 BTB (POZ) domain Similarity: Contains 5 Kelch repeats

Koetan hahmottaa rakennetta ja verrata esim  gigaxoniin, onko jotain tai mitään  samaa sekvenssipätkää) Kesken...Minkälainen Znf?


 KBTBD3,https://www.ncbi.nlm.nih.gov/gene/143879

Also known as

BKLHD3

Expression

Ubiquitous expression in brain (RPKM 1.9), thyroid (RPKM 1.3) and 25 other tissues See more

Orthologs

mouse all

       ##Evidence-Data-END##
FEATURES             Location/Qualifiers
     source          1..533
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q22.3"
     Protein         1..533
                     /product="kelch repeat and BTB domain-containing protein 3
                     isoform 2"
                     /note="BTB and kelch domain containing 3; kelch repeat and
                     BTB domain-containing protein 3; BTB and kelch
                     domain-containing protein 3; kelch repeat and BTB (POZ)
                     domain containing 3; epididymis secretory sperm binding
                     protein"
                     /calculated_mol_wt=60545
     Region          16..507
                     /region_name="BTB"
                     /note="Broad-Complex, Tramtrack and Bric a brac; cl28614"
                     /db_xref="CDD:333434"
     Region          255..310
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          314..362
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          365..410
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     Region          462..507
                     /region_name="KELCH repeat"
                     /note="KELCH repeat [structural motif]"
                     /db_xref="CDD:276965"
     CDS             1..533
                     /gene="KBTBD3"
                     /gene_synonym="BKLHD3"
                     /coded_by="NM_001330359.1:633..2234"
                     /note="isoform 2 is encoded by transcript variant 3"
                     /db_xref="CCDS:CCDS81621.1"
                     /db_xref="GeneID:143879"
                     /db_xref="HGNC:HGNC:22934"
ORIGIN      
        1 mfevnmkerd dgsvtitnls skavkafldy aytgktkitd dnvemffqls sflqvsflsk
       61 acsdfliksi nlvnclqlls isdsygstsl fdhalhfvqh hfsllfkssd flemnfgvlq
      121 kclesdelnv peeemvlkvv lswtkhnles rqkylphlie kvrlhqlsee tlqdclfnee
      181 sllkstncfd iimdaikcvq gsgglfpdar psttekyifi hkteengenq ytfcyniksd
      241 swkilpqshl idlpgsslss ygekifltgg ckgkccrtvr lhiaesyhda tdqtwcycpv
      301 kndfflvstm ktprtmhtsv maldrlfvig gktrgsrdik slldvesynp lskewisvsp
      361 lprgiyypea stcqnviyvl gseveitdaf npsldcffky nattdqwsel vaefgqffha
      421 tlikavpvnc tlyicdlsty kvysfcpdtc vwkgegsfec agfnagaigi edkiyilggd
      481 yapdeitdev qvyhsnrsew eevspmpral tefycqviqf nkyrdpwfsn lca
//

https://www.ncbi.nlm.nih.gov/pubmed/?term=KBTBD3

VERTAA GIGAXONIINI sekvenssiin,  KLHL16:

ORIGIN      
        1 maegsavsdp qhaarllral ssfreesrfc dahlvldgee ipvqknilaa aspyirtkln
       61 ynppkddgst ykielegisv mvmreildyi fsgqirlned tiqdvvqaad lllltdlktl
      121 cceflegcia aencigirdf alhyclhhvh ylateyleth frdvssteef lelspqklke
      181 visleklnvg neryvfeavi rwiahdteir kvhmkdvmsa lwvsgldssy lreqmlnepl
      241 vreivkecsn iplsqpqqge amlanfkprg ysecivtvgg eervsrkpta amrcmcplyd
      301 pnrqlwiela plsmprinhg vlsaegflfv fggqdenkqt lssgekydpd antwtalppm
      361 nearhnfgiv eidgmlyilg gedgekelis mecydiyskt wtkqpdltmv rkigcyaamk
      421 kkiyamgggs ygklfesvec ydprtqqwta icplkerrfg avacgvamel yvfggvrsre
      481 daqgsemvtc ksefyhdefk rwiylndqnl cipasssfvy gavpigasiy vigdldtgtn
      541 ydyvrefkrs tgtwhhtkpl lpsdlrrtgc aalrianckl frlqlqqglf rirvhsp
//