Onko ensin gliaalinen ja sitten vasta aksonaalinen tauopatia?
Abstract
Tauopathies
are a class of neurodegenerative diseases characterized by the presence
of hyperphosphorylated and aggregated tau pathology in neuronal and
glial cells. Though the ratio of neuronal and glial tau aggregates
varies across diseases, glial tau aggregates can populate the same
degenerating brain regions as neuronal tau aggregates. While much is
known about the deleterious consequences of tau pathology in neurons,
the relative contribution of glial tau pathology to these diseases is
less clear. Recent studies using a number of model systems implicate
glial tau pathology in contributing to tauopathy pathogenesis. This
review aims to highlight the functional consequences of tau
overexpression in glial cells and explore the potential contribution of
glial tau pathology in the pathogenesis of neurodegenerative
tauopathies.
Keywords: tau, tauopathy, glial tau pathology, functional consequences, neurodegeneration, astrocytes, oligodendrocytes, microglia
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