Viljellyllä punaisella merilevällä vaikuttaa olevan jotain estävää vaikutusta beta-amyloidin aiheuttamaa myrkyllisyyttä vastaan C.elegans-madon koe-maillissa. Matoon oli ensin transgeenisesti siirretty ihmisen Abeta(1-42) geeni. Tästä johtui että mato-koemallissa kehittyi Abetan toksisuudesta aiheutuva halvaus. Punalevävalmisteilla saatiin vastavaikutetua tähän myrkyllisyyteen. Hyvän vaikutuksen mekanismina oli beta-amyloidilajien määrän vähentyminen ja stressin indusoimien geenien ylössäätyminen ja vapaitten radikaalien kertymän vähentyminen.
Mar Drugs. 2015 Oct 20;13(10):6407-24. doi: 10.3390/md13106407. A Cultivated Form of a Red Seaweed (Chondrus crispus), Suppresses β-Amyloid-Induced Paralysis in Caenorhabditis elegans.
Abstract
We report here the protective effects of a methanol extract from a cultivated strain of the red seaweed, Chondrus crispus,
against β-amyloid-induced toxicity, in a transgenic Caenorhabditis
elegans, expressing human Aβ1-42 gene. The methanol extract of C. crispus
(CCE), delayed β-amyloid-induced paralysis, whereas the water extract
(CCW) was not effective. The CCE treatment did not affect the transcript
abundance of amy1; however, Western blot analysis revealed a
significant decrease of Aβ species, as compared to untreated worms. The
transcript abundance of stress response genes; sod3, hsp16.2 and skn1
increased in CCE-treated worms. Bioassay guided fractionation of the CCE
yielded a fraction enriched in monogalactosyl diacylglycerols (MGDG)
that significantly delayed the onset of β-amyloid-induced paralysis.
Taken together, these results suggested that the cultivated strain of C.
crispus,
whilst providing dietary nutritional value, may also have significant
protective effects against β-amyloid-induced toxicity in C. elegans,
partly through reduced β-amyloid species, up-regulation of stress
induced genes and reduced accumulation of reactive oxygen species (ROS).
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