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onsdag 30 mars 2011

Sulforafaanin osuus väitöskirjassa

Sahlgrenska Academy / Sahlgrenska akademin >
Institute of Neuroscience and Physiology / Inst för neurovetenskap och fysiologi >
Doctoral Theses / Doktorsavhandlingar >Reactive gliosis in the injured brain: The effect of cell communication and Nrf2-mediated cellular defence Please use this identifier to cite or link to this item: http://hdl.handle.net/2077/23937


II. Repeated transient sulforaphane stimulation in astrocytes leads to prolonged Nrf2-mediated gene expression and protection from superoxide-induced damage. Petra Bergström*, Heléne C. Andersson*, Yue Gao, Jan-Olof Karlsson, Christina Nodin, Michelle F. Anderson, Michael Nilsson, Ola Hammarsten

III. The effect of sulforaphane on infarct size, glial activation, cell proliferation and functional outcome following photothrombotic stroke in mice. Heléne C. Andersson, Linda Hou, Åsa Nilsson, Marcela Pekna, Milos Pekny, Michelle J. Porritt, Michael Nilsson Unpublished manuscript

Abstract: Stroke and other brain injuries trigger an extensive glial cell response referred to as reactive gliosis. Reactive gliosis is characterized by hypertrophic and proliferating astrocytes, proliferating microglia and NG2-positive cells, which eventually form a bordering glial scar around the damaged area. Although reactive gliosis may protect the injured brain initially, the resulting glial scar inhibits neuronal regeneration. This thesis focuses on the role of intercellular communication and endog... more
ISBN: 978-91-628-8242-6
URI: http://hdl.handle.net/2077/23937

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