Huomaan että tämä cGMP muodostus on hyvin altis epätasapainolle ja guanylyylisyklaasialueella on kaikenaisia tauteja. En löytänyt tästä nyt erikseen NO-GC1 tai NO-GC2 nimisena neuronin transmityeritasapainoon vaikuttavia geenejä mainittuna juuri näillä nimillä, joten en tiedä mihin kromosomiin ne projisoituvat ja mihin tauteihin esim neuroendokrinologisiin ne assosioituisivat. Jätän tähän ja jos tulee vastaan, lisään tästä GLU-GABA- neuronaalisen vapautumisen tasapainon hienosäädöstä, niin laitan sitten myöhemmin. Sekin tasapaino ilmeisesti on mennyt ihmiskunnassa vinoon, siten että normaalitasapainoa ei enää saada takaisin ainakaan ilman strategioiden muuttamista. GLU-GABA tasapainoa voisi sanoa tavallaan "neuronin kävelytahdiksi" sikäli että kävellessä täytyy todella olla järjestys saman asian hyväksi, tietysti luonnossa kyllä voi mennä kuin tintti, mutta tässä vertauskuvallisesti: toinen jalka alkaa yhteen suuntaan ja automaattisesti toinen jatkaa saman suuntaan asian hyväksi" tämä on maksimaalisesti näkyvissä niissä häiriöissä, mitkä tulee motoriikassa PD-taudissa, mutta häiriö voi alkaa jo tästä GLU-GABA alkuvapautumisin minimaalisen aikaeron hienosäädön katoamisesta. Joka ainut tahdonalainen impulssi menee hierarkisen hienosäätöverkoston modulatioon.
Nimiä
Nimiä
CUCY1A1 = CUCY1A3 = CUCA3 Kr.4
Soluble guanylate cyclases are heterodimeric proteins that catalyze the
conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein
encoded by this gene is an alpha subunit of this complex and it
interacts with a beta subunit to form the guanylate cyclase enzyme,
which is activated by nitric oxide, NO. Several transcript variants encoding
a few different isoforms have been found for this gene. [provided by
RefSeq, Jan 2012]
CUCY1A2, Kr.11
Soluble guanylate cyclases are heterodimeric proteins that catalyze
the conversion of GTP to 3',5'-cyclic GMP and pyrophosphate. The protein
encoded by this gene is an alpha subunit of this complex and it
interacts with a beta subunit to form the guanylate cyclase enzyme,
which is activated by nitric oxide,NO. Two transcript variants encoding
different isoforms have been found for this gene. [provided by RefSeq,
Jan 2012]Expression Broad expression in endometrium (RPKM 8.8), placenta (RPKM 7.4) and 15 other tissues
GUCY1A4 =CUSY2D Kr.17, Retinal
This gene encodes a retina-specific guanylate cyclase, which is a member
of the membrane guanylyl cyclase family. Like other membrane guanylyl
cyclases, this enzyme has a hydrophobic amino-terminal signal sequence
followed by a large extracellular domain, a single membrane spanning
domain, a kinase homology domain, and a guanylyl cyclase catalytic
domain. In contrast to other membrane guanylyl cyclases, this enzyme is
not activated by natriuretic peptides. Mutations in this gene result in
Leber congenital amaurosis and cone-rod dystrophy-6 diseases.
NPR1 = CUCY2A , Kr.1
This gene encodes natriuretic peptide receptor B, one of two integral
membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain
five functional domains: an extracellular ligand-binding domain, a
single membrane-spanning region, and intracellularly a protein kinase
homology domain, a helical hinge region involved in oligomerization, and
a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is
the primary receptor for C-type natriuretic peptide (CNP), which upon
ligand binding exhibits greatly increased guanylyl cyclase activity.
Mutations in this gene are the cause of acromesomelic dysplasia
Maroteaux type. [provided by RefSeq, Jul 2008]
NPR2= CUCY2B, Kr,.9
Guanylyl cyclases, catalyzing the production of cGMP from GTP, are
classified as soluble and membrane forms (Garbers and Lowe, 1994 [PubMed
7982997]). The membrane guanylyl cyclases, often termed guanylyl
cyclases A through F, form a family of cell-surface receptors with a
similar topographic structure: an extracellular ligand-binding domain, a
single membrane-spanning domain, and an intracellular region that
contains a protein kinase-like domain and a cyclase catalytic domain.
GC-A and GC-B function as receptors for natriuretic peptides; they are
also referred to as atrial natriuretic peptide receptor A (NPR1) and
type B (NPR2; MIM 108961). Also see NPR3 (MIM 108962), which encodes a
protein with only the ligand-binding transmembrane and 37-amino acid
cytoplasmic domains. NPR1 is a membrane-bound guanylate cyclase that
serves as the receptor for both atrial and brain natriuretic peptides
(ANP (MIM 108780) and BNP (MIM 600295), respectively).[supplied by OMIM,
May 2009]
GUCY2C Kr.12
Guanylate cyclase 2C
This observational study demonstrated the protein expression of GCC
across various gastrointestinal malignancies. In all cancer histotypes,
GCC protein localization was observed predominantly in the cytoplasm
compared to the membrane region of tumor cells. Consistent
immunohistochemistry detection of GCC protein expression in primary
colorectal cancers and in their matched liver metastases suggests that
the expression of GCC is maintained throughout the process of tumor
progression and formation of metastatic disease.
CUSY2F , Kr.X
The protein encoded by this gene is a guanylyl cyclase found
predominantly in photoreceptors in the retina. The encoded protein is
thought to be involved in resynthesis of cGMP after light activation of
the visual signal transduction cascade, allowing a return to the dark
state. This protein is a single-pass type I membrane protein. Defects in
this gene may be a cause of X-linked retinitis pigmentosa. [provided by
RefSeq, Dec 2008]
CUCA 1B =CUCA2 , Kr.6
Search results
Items: 15
| Name/Gene ID | Description | Location | Aliases | MIM |
|---|---|---|---|---|
| guanylate cyclase 2C [Homo sapiens (human)] | Chromosome 12, NC_000012.12 (14612632..14696625, complement) | DIAR6, GC-C, GUC2C, MECIL, MUCIL, STAR | 601330 | |
| natriuretic peptide receptor 1 [Homo sapiens (human)] | Chromosome 1, NC_000001.11 (153678649..153693992) | ANPRA, ANPa, GUC2A, GUCY2A, NPRA | 108960 | |
| guanylate cyclase 2D, retinal [Homo sapiens (human)] | Chromosome 17, NC_000017.11 (8002670..8020340) | CACD1, CORD5, CORD6, CYGD, GUC1A4, GUC2D, LCA, LCA1, RCD2, RETGC-1, ROS-GC1, ROSGC, retGC | 600179 | |
| natriuretic peptide receptor 2 [Homo sapiens (human)] | Chromosome 9, NC_000009.12 (35782086..35809731) | AMDM, ANPRB, ANPb, ECDM, GUC2B, GUCY2B, NPRB, NPRBi, SNSK | 108961 | |
| glucagon [Homo sapiens (human)] | Chromosome 2, NC_000002.12 (162142869..162152404, complement) | GLP-1, GLP1, GLP2, GRPP | 138030 | |
| adenylate cyclase 5 [Homo sapiens (human)] | Chromosome 3, NC_000003.12 (123282296..123448988, complement) | AC5, FDFM | 600293 | |
| guanylate cyclase 1 soluble subunit alpha 1 [Homo sapiens (human)] | Chromosome 4, NC_000004.12 (155666710..155737062) | GC-SA3, GUC1A3, GUCA3, GUCSA3, GUCY1A3, MYMY6 | 139396 | |
| adenylate cyclase 1 [Homo sapiens (human)] | Chromosome 7, NC_000007.14 (45574140..45723116) | AC1, DFNB44 | 103072 | |
| adenylate cyclase 6 [Homo sapiens (human)] | Chromosome 12, NC_000012.12 (48766191..48789096, complement) | AC6, LCCS8 | 600294 | |
| adenylate cyclase 8 [Homo sapiens (human)] | Chromosome 8, NC_000008.11 (130780300..131041604, complement) | AC8, ADCY3, HBAC1 | 103070 | |
| guanylate cyclase 2F, retinal [Homo sapiens (human)] | Chromosome X, NC_000023.11 (109372061..109482056, complement) | CYGF, GC-F, GUC2DL, GUC2F, RETGC-2, ROS-GC2 | 300041 | |
| guanylate cyclase 1 soluble subunit alpha 2 [Homo sapiens (human)] | Chromosome 11, NC_000011.10 (106674012..107018445, complement) | GC-SA2, GUC1A2 | 601244 | |
| adenylate cyclase 2 [Homo sapiens (human)] | Chromosome 5, NC_000005.10 (7396230..7830081) | AC2, HBAC2 | 103071 | |
| adenylate cyclase 4 [Homo sapiens (human)] | Chromosome 14, NC_000014.9 (24318349..24335071, complement) | AC4 | 600292 | |
| guanylate cyclase activator 1B [Homo sapiens (human)] | Chromosome 6, NC_000006.12 (42183284..42194956, complement) | GCAP2, GUCA2, RP48 | 602275 |
Inga kommentarer:
Skicka en kommentar