SAPLIP saposiinien perheestä. EI-ENTSYMAATTISIA PIENIÄ MOLEKYYLEJÄ.Vahingollisen Psykosiinivälituotteen akkumuloitumisen estäjIä

 https://www.genecards.org/cgi-bin/carddisp.pl?gene=PSAP&keywords=Psychosine

https://www.genecards.org/cgi-bin/carddisp.pl?gene=PSAP&keywords=PSAP

Psychosiini eli galaktoosisfingosiini on  välituote, jonka pitoisuus on hyvin matala normaalisti ja siitä tulee vapaata  D-galaktoosia ja  sfingosiinia. ,jotka ovat oligodendrosyyteille neurotoksisia. 

Saponiinien joukko siivoaa näitä ja nopeuttaa  myeliiniin asettuvien  glykolipidien    degradaatiota.. aivojen lipidien turnover prosessissa.  SAPLIP family:

PSAP 10q21.1

Aliases for PSAP Gene

• GeneCards Symbol: PSAP 2 
• Prosaposin 2 3 4 5
• GLBA 3 4 5
• SAP1 3 4 5
• Sphingolipid Activator Protein-1 2 3
• Sphingolipid Activator Protein-2 2 3
• Proactivator Polypeptide 3 4
• Precursor Of Saposins 2 3

• Saposin-A 2 3
• Saposin-B 2 3
• Saposin-C 2 3
• Saposin-D 2 3
• SAP2 3 5
• Variant Gaucher Disease And Variant Metachromatic Leukodystrophy 2
• PARK24 3

• UniProtKB/Swiss-Prot Summary for PSAP Gene

  Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. ( SAP_HUMAN,P07602 )

  Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. ( SAP_HUMAN,P07602 )

  Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). ( SAP_HUMAN,P07602 )

  [Prosaposin]: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling. ( SAP_HUMAN,P07602 )

  Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases. ( SAP_HUMAN,P07602 )

Post-translational modifications for PSAP Gene

• The lysosomal precursor is proteolytically processed to 4 small peptides, which are similar to each other and are sphingolipid hydrolase activator proteins. ( P07602-SAP_HUMAN )
• N-linked glycans show a high degree of microheterogeneity. ( P07602-SAP_HUMAN )
• The one residue extended Saposin-B-Val is only found in 5% of the chains. ( P07602-SAP_HUMAN )
• Glycosylation at Asn80, Asn101, Asn136, Thr214, Asn215, Ser216, Thr217, Asn332, Thr397, Thr401, and Asn426 ( NX_P07602 [NX_P07602-1] )
• Modification sites at PhosphoSitePlus ( P07602 )
• Glycosylation from GlyConnect 
  • SAP_HUMAN (1645)
• Glycosylation from GlyGen (P07602) 23 sites, 291 N-linked glycans (7 sites), 1 N-linked;o-linked glycan (2 sites), 4 O-linked glycans (16 sites)